DNA methylation is known as an important regulation of genome function. It has effects on the binding affinity between DNA and DNA binding proteins, resulting to varies of biological results. DNA methylation can be a dynamic process for altering gene activity temporarily, or be long-term changes upon cell differentiation/ cell fate commitment. It plays roles in epigenetic regulation on genome functions. Using bisulfite conversion of genomic DNA combining with next-generation sequencing (BS Seq), the 5-mehtylcytosine level of all available C residues in the whole genome scale can be detected.

Data Modules

Overviews of the data modules in TEA

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Find Genes by Text Search

Search the gene of your interest.

Find Genes by Values

DMGs and mC Threshold modules provide two different ways to access methylation landscapes in six different contexts.

Gene List Analysis

View the gene sets from different analytic approaches.

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To fasiliate the access of the BS Seq data for model plant Arabidopsis researchers, we build the TEA workbench. Mapping reports of two popular bisulfite sequence mapping program, *.CGmap from BS Seeker 2, and *.CX_report.txt from Bismark , are supported.

Present compatible reference genome/annotation in TEA is TAIR10. We adopt a summarized score to indicate the methylation level of three different 5-methylC sequence contexts (CG, CHG, CHH) for each "promoter" and "gene-body" each protein coding gene. Please check the BS Seq mapping process if you are also not familiar with the usage of mapping tools.